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TitleExtensive Concerted Evolution of Rice Paralogs and the Road to Regaining Independence
AuthorsXiyin Wang, Haibao Tang, John E. Bowers, Frank A. Feltus and Andrew H. Paterson
Year2007
Taxonrice
PDF1753.pdf
PublicationGenetics 177: 1753-1763
Journal_link
Publisher_note
Supplemental
AbstractMany genes duplicated by whole-genome duplications (WGDs) are more similar to one another than
expected. We investigated whether concerted evolution through conversion and crossing over, well-known
to affect tandem gene clusters, also affects dispersed paralogs. Genome sequences for two Oryza
subspecies reveal appreciable gene conversion in the ~0.4 MY since their divergence, with a gradual
progression toward independent evolution of older paralogs. Since divergence from subspecies indica,
~8% of japonica paralogs produced 5-7 MYA on chromosomes 11 and 12 have been affected by gene
conversion and several reciprocal exchanges of chromosomal segments, while ~70-MY-old "paleologs"
resulting from a genome duplication (GD) show much less conversion. Sequence similarity analysis in
proximal gene clusters also suggests more conversion between younger paralogs. About 8% of paleologs
may have been converted since rice-sorghum divergence ~41 MYA. Domain-encoding sequences are
more frequently converted than nondomain sequences, suggesting a sort of circularity - that sequences
conserved by selection may be further conserved by relatively frequent conversion. The higher level of
concerted evolution in the 5-7 MY-old segmental duplication may reflect the behavior of many genomes
within the first few million years after duplication or polyploidization.

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