One can fly to Athens via USAir, connecting in Charlotte, but it is often more expensive and less convenient than flying to Atlanta and either renting a car (probably the better option for two, about a 70 mile drive), or taking the airport shuttle, Groome Transportation. The shuttle regularly stops at the Georgia Center for Continuing Education (1-706-542-6364), which is also a good place to stay.  The shuttle also stops at most of the major hotels, see below.
 
There is convenient and reasonably good lodging on campus, in the hotel of the Georgia Center for Continuing Education, 1-706-542-6364 for reservations.  It is also a regularly-scheduled stop for the shuttle.  By request, they can also fax you a map of how to get there from Atlanta.  They also have campus maps, although they may not be familiar with my building (the Center for Applied Genetic Technologies, look for Room 227 or call 583-0166 or 0162).  If not, ask them to direct you to the CCRC (Complex Carbohydrate Research Center) which is down the street from us.
 
A sampling of other alternatives that might be cheaper than the Georgia Center would be:
 
Best Inn, 2715 Atlanta Highway, 1-706-549-1530 Perimeter Inn, 3791 Atlanta Highway, 1-706-548-3000
Holiday Inn Express, 513 W. Broad Street, 706-546-8122 Super8 motel, 3425 Atlanta Highway, 706-549-0251
Howard Johnson, 2465 W. Broad St., 706-548-1111 Travelodge, 898 W. Broad St, 706-549-0251

If you drive, the best route from Atlanta is to take I-285 loop (depending on exactly where you get on, it may be marked East or North; it changes near the airport)  from the airport to I-20 East. Stay on I-20 to Conyers, then GA HWY 138 North until it merges with GA HWY 78 East. Just outside Athens, immediately after a conspicuous Oconee State Bank, 78 splits into business (straight, but avoid it), and bypass (take it, to the right). Stay on the 78 East bypass (also called the Paul Broun Parkway along part of its length) until you see an exit for College Station Road.  Get off at the exit, turn right onto College Station Road, drive up a small hill about 100 yards (90 meters), and turn right onto Riverbend Road. My lab is in the first building on the left, my office is Room 228 (inside Room 227). Phone 1-706-583-0162 (0166 if no answer).  The Atlanta Highway and Broad Street are the same thing, the main drag through the center of Athens, and are also known as GA HWY 78. 

Information about the environment, etc, can be found at the UGA website or Yahoo's Athens, GA site The Graduate Student Association page provides an excellent resource for those seeking housing information.